Cozen O’Connor: Nonlinear Dynamic Modeling of Synaptically Driven Single Hippocampal Neuron Intracellular Activity [IEEE Transactions on Biomedical Engineering]

Nonlinear Dynamic Modeling of Synaptically Driven Single Hippocampal Neuron Intracellular Activity [IEEE Transactions on Biomedical Engineering]

Ude Lu, a member of Cozen O'Connor's Intellectual Property Department, discusses this topic in IEEE Transactions on Biomedical Engineering. A high-order nonlinear dynamic model of the input-output properties of single hippocampal CA1 pyramidal neurons was developed based on synaptically driven intracellular activity. The purpose of this study is to construct a model that: 1) can capture the nonlinear dynamics of both subthreshold activities [postsynaptic potentials (PSPs)] and suprathreshold activities (action potentials) in a single formalism; 2) is sufficiently general to be applied to any spike-input and spike-output neurons (point process input and point process output neural systems); and 3) is computationally efficient.

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Ude Lu, Ph.D.

Associate

ulu@cozen.com

(202) 471-3404


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